Table 4. Relationship among LDL-C levels estimated based on the Friedewald and Martin methods and methylation levels of the LPL, ADRB3, and MTHFR genes and demographic, epidemiological, lifestyle and anthropometric variables.
| Model 6—Response LDL-C Martin | ||||
| Variable | Coefficient | LB-UB (95%) | Z statistic | p-value |
| Intercept | 26.70 | 7.63 ± 45.77 | 1.40 | 0.163 |
| LPL gene | 3.16 | -8.61 ± 14.93 | 0.27 | 0.789 |
| ADRB3 gene | -9.42 | -22.14 ± 3.30 | -0.74 | 0.460 |
| MTHFR gene | 10.58 | -2.06 ± 23.22 | 0.84 | 0.404 |
| Age | 0.80 | 0.59 ± 1.01 | 3.86 | 0.000* |
| Waist circumference | 0.51 | 0.35 ± 0.67 | 3.21 | 0.001* |
| Model 5—Response variable: LDL-C Friedewald | ||||
| Intercept | 42.35 | 19.96 ± 64.74 | 1.89 | 0.060 |
| LPL gene | 13.02 | -7.92 ± 18.87 | 0.90 | 0.367 |
| ADRB3 gene | -1.42 | -15.92 ± 13.08 | -0.10 | 0.922 |
| MTHFR gene | 14.00 | -0.39 ± 28.39 | 0.97 | 0.331 |
| Age | 0.50 | 0.26 ± 0.73 | 2.11 | 0.036* |
| Waist circumference | 0.42 | 0.24 ± 0.60 | 2.33 | 0.020* |
Model adjusted for demographic, epidemiological, lifestyle and anthropometric variables included in the explanatory model
*: p < 0.005; LDL-C: low-density lipoprotein cholesterol; LB: lower boundary; UB: Upper boundary.