Skip to main content
. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Liver Res. 2020 Sep 25;4(4):161–167. doi: 10.1016/j.livres.2020.09.003

Fig. 2. Schematic illustration of the mechanisms by which GP73 expression is regulated.

Fig. 2.

GP73 is regulated by HBsAg, cytokines, hyper-activated mTORC1, HIF-2α, and miRNA. GP73 promotes the occurrence and development of HCC through inhibition of apoptosis and autophagy, as well as promoting EMT. This figure was generated using tools available in the BioRender.com. Abbreviations: DEPTOR, DEP-domain containing mTOR-interacting protein; EMT, epithelial-mesenchymal transition; GP73, Golgi protein 73; HBV, hepatitis B virus; HIF-2α, hypoxia inducible factors-2alpha; IFN-γ, interferon-gamma; IL, interleukin; mLST8, mammalian lethal with SEC13 protein 8; mTOR, mechanistic target of rapamycin; mTORC1, mechanistic target of rapamycin complex 1; PRAS40, prolin-rich Akt substrate of 40 kD; RAPTOR, regulatory-associated protein of mammalian target of rapamycin; STAT3, signal transducer and activator of transcription 3; TNF-α, tumor necrosis factor-alpha.