TABLE 4.
Mood Rating Scale composite scores by treatment cohort a
| MRS score b | Placebo (N = 6) | Allo 2 mg (N = 6) | Allo 4 mg (N = 6) | Allo 6–18 mg (N = 6) | P‐value c |
|---|---|---|---|---|---|
| Alertness d | 75 (65–86) | 84 (73–94) | 67 (56–78) | 58 (48–69) | 0.006 |
| Mental sedation e | 76 (65–88) | 80 (69–91) | 66 (55–78) | 52 (41–63) | 0.002 |
| Physical sedation f | 74 (63–85) | 86 (75–97) | 69 (58–80) | 60 (49–71) | 0.01 |
Numbers in table are mean (95% confidence interval).
MRS range is 0–100 with lower scores indicating increased sedation.
Linear mixed model with random subject effect was used to compare mean MRS scores among treatment cohorts. P‐value represents overall difference across all treatment cohorts. Dunnett's method was used for multiple comparisons between each Allo cohort with placebo. The mean difference in mental sedation between Allo 6–18 mg and placebo is significant (P = 0.007). The difference in alertness between Allo 6–18 mg placebo is marginally significant (P = 0.07). All other P‐values >0.17.
Alertness is the average of scores for (a) alert/drowsy, (b) clear‐headed/muzzy, (c) quick‐witted/mentally slow, (d) attentive/dreamy, (e) strong/feeble, (f) well‐coordinated/clumsy, (g) energetic/lethargic, (h) proficient/incompetent, and (i) interested/bored.
Mental sedation is a subcomponent of Alertness (average of scores a, b, c, d).
Physical sedation is a subcomponent of Alertness (average of scores e, f, g, h).
Abbreviation: MRS, Mood Rating Scale.