Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 16;6(51):eabe6393. doi: 10.1126/sciadv.abe6393

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 2 — (A and B) Representative bright-field (left) and fluorescent images (right) of lamellar cells from Pacinian and Meissner corpuscles filled with Lucifer yellow via the recording electrode. A glass probe is positioned nearby to deliver mechanical stimulation. (C) Electrophysiological characteristics of lamellar cells. Significance was calculated using unpaired two-tailed t test. Open circles denote individual cells. (D) Representative MA currents elicited from lamellar cells by mechanical indentation using a glass probe. (E) Quantification of peak MA current amplitude in Pacinian (left, n = 19 cells) and Meissner (right, n = 7 cells) lamellar cells in response to indentation with a glass probe. Lines connect measurements from individual cells. (F) Quantification of MA current rise time (τ_rise) recorded in lamellar cells and in duck trigeminal mechanoreceptors with fast, intermediate, and slow MA current. The difference between means is significant; F_4,61 = 3.49, P = 0.013, one-way analysis of variance (ANOVA) with Tukey’s post hoc multiple comparisons test. Open circles denote individual cells. (G) Quantification of MA current inactivation rate (τ_decay) recorded in lamellar cell and duck trigeminal mechanoreceptors. τ_decay values greater than 1000 ms are plotted as 1000. Bars represent median. Open circles denote individual cells. The difference between medians is significant; P < 0.0001, Kruskal-Wallis test. ***P < 0.0001, Dunn’s post hoc multiple comparisons test. (H) Representative MA currents elicited from lamellar cells in response to indentation at different voltages. (I) Voltage dependence of peak MA current from eight Pacinian and five Meissner lamellar cells, fitted to the linear equation. (J) Quantification of MA current τ_decay from seven Pacinian and seven Meissner lamellar cells, fitted to the linear equation. r, Pearson’s correlation coefficient; P denotes the probability of the line slope being equal to 0. Data are presented as means ± SEM from at least three independent skin preparations.