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. 2020 Dec 16;6(51):eabc8355. doi: 10.1126/sciadv.abc8355

Fig. 8. KIF17 3′UTR is essential for fear extinction.

Fig. 8

(A) Freezing scores during the contextual fear extinction test. The Kif17 3′UTR2lox/2lox mice that received an AAV-Cre–mediated deletion of Kif17 3′UTR failed in fear extinction. Effects of treatment (P < 0.001) and time (P < 0.001), two-way ANOVA; *P < 0.05, **P < 0.01, ***P < 0.001, Bonferroni’s post hoc comparison. n = 6 mouse pairs. (B) Genomic PCR of the hippocampal lysates of the Kif17 3′UTR2lox/2lox mice at 4 weeks after the injections of the indicated AAV vector including AAV-Cre-GFP. (C) Freezing scores during the contextual fear extinction test. An AAV-mediated Kif17 3′UTR introduction to the mice that received an AAV-Cre–mediated deletion of Kif17 3′UTR specifically rescued the fear extinction impairment but not Kif17 without 3′UTR introduction. Effects of treatment (P < 0.001) and time (P < 0.001), two-way ANOVA; *P < 0.05, **P < 0.01, ***P < 0.001, Bonferroni’s post hoc comparison. n = 7 mouse pairs.