Figure 1.

Subdoligranulum is associated with Akkermansia muciniphila and correlates positively with a healthy metabolic status

(A) Subset of the co-abundance network inferred using the SCS method related to the Akkermansia and Suddoligranulum genera. Nodes indicate metagenomic species and the two target genera, while edges indicate the inferred associations. Direction of the edges displays causal inference while the red and blue colors indicate respectively positive and negative associations. The colors of the vertices depict the different phylogenetic annotations at the family level – black being the two targets and white unknown phylogenetic annotations. (B) Heatmap of Spearman correlations between metagenomic species and clinical variables. ‘+’ indicates significant associations resisting adjustment for multiple testing while ‘*,’ associations which do not resist. N = 108.