Table 1.
The levels of the independent variables in a 23 full-factorial design for the evaluation of FTN-loaded PCs and the optimization criterion for the dependent variables.
| Factors (independent variables) | Levels |
|
|---|---|---|
| Low | High | |
| X1: Ceramide amount (mg) | 15 | 30 |
| X2: Brij type | Brij52 | Brij97 |
| X3: Brij amount (mg) | 5 | 15 |
| Responses (dependent variables) | Constraints | |
| Y1: EE (%) | Maximize | |
| Y2: PS (nm) | Minimize | |
| Y3: PDI | – | |
| Y4: ZP | Maximize | |
EE%: entrapment efficiency percent; FTN: fenticonazole nitrate; PS: particle size; PDI: polydispersity index; ZP: zeta potential; PCs: PEGylated cerosomes.