Table 2.
Experimental runs composition corresponding to the 23 full factorial design for FTN-loaded PC formulation and their resultant dependent variables.
| Ceramide amount (mg) | Brij type | Brij amount (mg) | EE% | PS (nm) | PDI | ZP (mV) | |
|---|---|---|---|---|---|---|---|
| PC1 | 15 | Brij 52 | 5 | 85.33 ± 1.24 | 458.00 ± 18.00 | 0.51 ± 0.03 | 18.50 ± 0.28 |
| PC2 | 30 | 99.33 ± 0.48 | 630.00 ± 9.20 | 0.53 ± 0.05 | 11.00 ± 0.38 | ||
| PC3 | 15 | Brij 97 | 82.66 ± 1.25 | 336.6 ± 12.35 | 0.50 ± 0.06 | 16.70 ± 0.35 | |
| PC4 | 30 | 92.33 ± 1.25 | 422.00 ± 21.96 | 0.84 ± 0.03 | 2.74 ± 0.13 | ||
| PC5 | 15 | Brij 52 | 15 | 77.00 ± 0.81 | 309.20 ± 9.06 | 0.56 ± 0.03 | 14.30 ± 0.14 |
| PC6 | 30 | 83.00 ± 1.63 | 551.60 ± 23.84 | 0.44 ± 0.05 | 20.90 ± 0.55 | ||
| PC7 | 15 | Brij 97 | 69.66 ± 0.47 | 361.50 ± 20.34 | 0.71 ± 0.07 | 2.80 ± 0.09 | |
| PC8 | 30 | 78.33 ± 2.86 | 392.50 ± 8.65 | 0.57 ± 0.02 | 7.92 ± 0.17 |
Data represented as mean ± SD (n = 3). EE%: entrapment efficiency percentage; FTN: fenticonazole nitrate; PS: particle size; PDI: polydispersity index; PC: PEGylated cerosomes.