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. 2020 Dec;6(4):315–324. doi: 10.18383/j.tom.2020.00043

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© 2020 The Authors. Published by Grapho Publications, LLC

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Figure 2. — Comparison of commercially available superparamagnetic iron oxide nanoparticles (SPIONs) using MPI relaxometry. Point spread functions (PSFs) show that the relative sensitivity of synomag-D is superior to that of micron-sized superparamagnetic polystyrene beads (MPIO), ferucarbotran, and ferumoxytol (in order) per gram of iron content (A). Normalized PSFs show that the resolution (full-width half maximum; FWHM) of ferucarbotran is superior to that of synomag-D, MPIO, and ferumoxytol (in order) (B). Measurements of sensitivity and resolution for each nanoparticle are outlined in (C). MPI of each individual SPION (30 µg) and the corresponding intensity profile is shown in (D). A single MPI image and intensity profile of all 4 SPIONs (30 µg) show similar results (E). MPI images are displayed in full-dynamic range.