Table 2.
Identification of significant pathways in the HF and healthy groups.
| NO. | Pathways | Total | Hits | P value | Metabolites | Impact |
|---|---|---|---|---|---|---|
| 1 | Alanine, aspartate and glutamate metabolism | 28 | 3 | 0.0035 | Citric acid, L-Aspartic acid, L-Glutamic acid |
0.420 |
| 2 | Glutathione metabolism | 28 | 2 | 0.0402 | L-Pyroglutamic acid, L-Glutamic acid |
0.027 |
| 3 | Arginine and proline metabolism | 38 | 2 | 0.0700 | 4-Guanidinobutyric acid, L-Glutamic acid |
0.086 |
| 4 | Vitamin B6 metabolism | 9 | 1 | 0.1000 | Pyridoxal | 0.490 |
| 5 | Arginine biosynthesis | 14 | 2 | 0.0139 | L-Glutamic acid, L-Aspartic acid |
0.1168 |
| 6 | Citrate cycle (TCA cycle) | 20 | 1 | 0.2095 | Citric acid | 0.090 |
| 7 | Purine metabolism | 65 | 2 | 0.1725 | Adenosine, Inosine |
0.0036 |
| 8 | Pyrimidine metabolism | 39 | 1 | 0.3695 | Uracil | 0.074 |
| 9 | Glyoxylate and dicarboxylate metabolism | 32 | 2 | 0.0514 | Citric acid L-Glutamic acid |
0.0318 |