Fig. 5.

Humoral and cellular immune responses observed in mice and baboons after vaccination with NVX-CoV2373 plus Matrix-M. (a) Two-dose regimen of NVX-CoV2373 (left) elicited stronger serum IgG response in mice, compared with single-dose regimen (right). Addition of Matrix-M further amplified the responses. (b) Vaccination study in baboons indicated generation of neutralizing serum IgG that blocked interaction between ACE2 and S protein (left) and viral infection to Vero E6 cells in vitro (right). (c) Cellular immune responses examined by ELISPOT assay (left) and intracellular staining assay (right). Reproduced with permission from [86].