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. 2020 Dec 3;13:610964. doi: 10.3389/fnmol.2020.610964

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Copyright © 2020 Rodríguez Cruz, Cossins, Beeson and Vincent.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the mouse NMJ development. (A) Aneural AChR clusters are pre-patterned in the midbelly of the muscle fibers prior to the arrival of the nerve terminal. (B) Upon innervation of the pre-patterned clusters in the synaptic region, they become enlarged while aneural clusters located in the extrasynaptic region disappear. (C) As a result, AChR clusters are concentrated at a high density in the area underneath the nerve terminal maximizing the efficiency of neuromuscular transmission. (D) Postnatal maturation of AChR clusters and plaque to pretzel transformation. (E) Fragmentation of AChR clusters with aging.