TABLE 2.

Molecules identified in NMJ formation, maturation and maintenance and levels of evidence.

	Molecule	Cellular level	Animal level	Human disease
NMJ formation	* Agrin	Ferns et al., 1993	Bogdanik et al., 2011	Huzé et al., 2009; Gasperi et al., 2014
	ß-catenin (muscle)	Zhang et al., 2007	Li et al., 2008	N/A
	Calpain	Chen et al., 2007	N/A	N/A
	CaMKII/PKC	Macpherson et al., 2002	N/A	N/A
	Cdk5	Fu et al., 2005	Fu et al., 2005	N/A
	Crk/CrkL	Hallock et al., 2010	Hallock et al., 2010	N/A
	Dihydropyridine-R	N/A	Chen et al., 2011	N/A
	* DOK7	Okada et al., 2006; Cossins et al., 2012	Okada et al., 2006; Arimura et al., 2014	Beeson et al., 2006
	Dvl1	Luo et al., 2002	Lijam et al., 1997	N/A
	* α-dystroglycan	Jacobson et al., 2001	Côté et al., 1999	Belaya, 2015
	Erm	N/A	Hippenmeyer et al., 2007	N/A
	FGF 7/10/22	Fox et al., 2007	Ohno et al., 1999	N/A
	GABP	Schaeffer et al., 1998	Schaeffer et al., 1998	N/A
	* Laminin ß2	Nishimune et al., 2004	Noakes et al., 1995	Matejas et al., 2010
	* LRP4	Zhang et al., 2008	Weatherbee et al., 2006; Yumoto et al., 2012	Higuchi et al., 2011; Ohkawara et al., 2013
	* MuSK	Koneczny et al., 2013	Chevessier et al., 2008; Cole et al., 2008	Hoch et al., 2001; Chevessier et al., 2004
	Myogenin	Eftimie et al., 1991	Arnold and Braun, 1996	N/A
	* N-glycosylation	Belaya et al., 2012; Zoltowska et al., 2013	Issop et al., 2018	Senderek et al., 2011; Belaya et al., 2012; Cossins et al., 2013; Belaya, 2015
	Nestin	Yang et al., 2011	Yang et al., 2011	N/A
	PAK1	Luo et al., 2002	N/A	N/A
	Perlecan	Peng et al., 1998	Arikawa-hirasawa et al., 2002	N/A
	Pro-BDNF	Yang et al., 2009	N/A	N/A
	Rac and Rho	Weston et al., 2003	N/A	N/A
	* Rapsyn	Cossins et al., 2006	Xing et al., 2019	Ohno et al., 2002
	SIRP-α	Umemori and Sanes, 2008	N/A	N/A
	Sorbs1 and Sorbs2	Hallock et al., 2016	N/A	N/A
	Tid1	Linnoila et al., 2008	N/A	N/A
NMJ maturation	* COL13A1	Latvanlehto et al., 2010	Latvanlehto et al., 2010	Logan et al., 2015
	CLASP2/CLIP170	Schmidt et al., 2012	Schmidt et al., 2012	N/A
	Ephexin1	Shi et al., 2010	Shi et al., 2010	N/A
	FGFBP1	N/A	Taetzsch et al., 2017	N/A
	GDNF	N/A	Nguyen et al., 1998	N/A
	Neurofascin 155	N/A	Roche et al., 2014	N/A
	Laminin α4	N/A	Nishimune et al., 2008	N/A
	* Laminin α5	N/A	Nishimune et al., 2008	Maselli et al., 2017
	* MACF1	Oury et al., 2019	Oury et al., 2019	Oury et al., 2019
	MHC1-I	N/A	Tetruashvily et al., 2016	N/A
	NRG1-III	N/A	Lee et al., 2016	N/A
	Vezatin	Koppel et al., 2019	Koppel et al., 2019	N/A
NMJ maintenance	* Agrin	Huzé et al., 2009	Samuel et al., 2012; Tezuka et al., 2014	Huzé et al., 2009
	α-dystrobrevin	Grady et al., 2000	Grady et al., 2000	N/A
	α-syntrophin	N/A	Adams et al., 2000	N/A
	CaMKII	N/A	Martinez-Pena et al., 2010	N/A
	* DOK7	Cossins et al., 2012	Eguchi et al., 2016	Beeson et al., 2006
	Laminin α4	N/A	Samuel et al., 2012	N/A
	* LRP4	Shen et al., 2013	Barik et al., 2014	Ohkawara et al., 2013
	* MuSK	Koneczny et al., 2013	Kong et al., 2004	Hoch et al., 2001
	* N-glycosylation	Belaya et al., 2012; Zoltowska et al., 2013	Issop et al., 2018	Senderek et al., 2011; Belaya et al., 2012; Cossins et al., 2013; Belaya, 2015
	NCAM	N/A	Rafuse et al., 2000	N/A
	Neuregulin/ErbB	N/A	Lin et al., 2000; Fu et al., 2005	N/A
	Neurotrypsin	N/A	Bolliger et al., 2010	N/A
	PKA/PKC	N/A	Martinez-Pena et al., 2013	N/A
	Sarcoglycan-alpha	N/A	Zhao et al., 2018	N/A
	Shp2	Madhavan et al., 2005	Dong et al., 2006	N/A
	Src-family kinases	Smith et al., 2001	N/A	N/A

*Molecules with the strongest evidence are marked with an asterisk; N/A, not available.