Table 1.
Baseline characteristics of 5979 men enrolled in MrOS, by Lower Urinary Tract Symptom (LUTS) Severity.
| Variable | None/Mild (AUASI 0–7) |
Moderate (AUASI 8–19) |
Severe (AUASI 20–35) |
P-value* |
|---|---|---|---|---|
| Sample size, n (%) | 3230 (54) | 2351 (39) | 398 (7) | |
| Demographics | ||||
| Age, years, mean ± SD | 73 ± 6 | 74 ± 6 | 75 ± 6 | <0.001 |
| College education, n (%) | 1707 (53) | 1275 (54) | 198 (50) | 0.22 |
| Married, n (%) | 2652 (82) | 1950 (83) | 316 (79) | 0.22 |
| Nonwhite race, n (%) | 339 (11) | 222 (9) | 46 (12) | 0.28 |
| Biometrics, mean ± SD | ||||
| Body mass index (BMI), kg/m2 | 27.3 ± 3.7 | 27.4 ± 4.0 | 27.7 ± 3.9 | 0.24 |
| Appendicular skeletal lean mass, kg | 24.3 ± 3.5 | 24.1 ± 3.5 | 24.3 ± 3.6 | 0.03 |
| Walking speed, m/s | 1.2 ± 0.2 | 1.2 ± 0.2 | 1.1 ± 0.3 | <0.001 |
| Grip strength, kg | 42 ± 8 | 41 ± 9 | 40 ± 9 | <0.001 |
| Questionnaires | ||||
| General Health Status, n (%) | <0.001 | |||
| Excellent | 1218 (38) | 711 (30) | 87 (22) | |
| Good | 1686 (52) | 1214 (52) | 205 (52) | |
| Fair | 292 (9) | 378 (16) | 89 (22) | |
| Poor or Very Poor | 34 (1) | 46 (2) | 17 (4) | |
| Feeling full of energy†, n (%) | 3070 (95) | 2096 (89) | 308 (77) | <0.001 |
| PASE score, mean ± SD | 151 ± 69 | 141 ± 66 | 134 ± 69 | <0.001 |
| ≥1 IADL limitation, n (%) | 489 (15) | 582 (25) | 151 (38) | <0.001 |
| Health Behaviors | ||||
| Smoking, n (%) | 0.004 | |||
| Never | 1245 (39) | 861 (37) | 137 (34) | |
| Past | 1853 (57) | 1430 (61) | 248 (62) | |
| Current | 132 (4) | 60 (3) | 13 (3) | |
| Drinking, n (%) | 0.35 | |||
| <1 drink/week | 1528 (47) | 1120 (48) | 210 (53) | |
| 1–13 drinks/week | 1537 (48) | 1117 (48) | 170 (43) | |
| ≥14 drinks/week | 165 (5) | 114 (5) | 18 (5) | |
| Health Conditions, N (%) | ||||
| Myocardial Infarction or Angina | 589 (18) | 573 (24) | 121 (30) | <0.001 |
| Heart Failure | 141 (4) | 143 (6) | 30 (8) | 0.002 |
| Hypertension | 1312 (41) | 1064 (45) | 199 (50) | <0.001 |
| Stroke or Parkinson’s Disease | 174 (5) | 169 (7) | 45 (11) | <0.001 |
| Diabetes | 343 (11) | 251 (11) | 58 (15) | 0.05 |
| Chronic Obstructive Pulmonary Disease | 277 (9) | 292 (12) | 68 (17) | <0.001 |
| Prostate Cancer | 389 (12) | 264 (11) | 52 (13) | 0.47 |
| Physiological Distress‡ | 416 (13) | 463 (20) | 94 (24) | <0.001 |
| Cognitive Impairment§ | 83 (3) | 66 (3) | 17 (4) | 0.15 |
| Multimorbidity¶ | <0.001 | |||
| 0 chronic conditions | 1582 (49) | 957 (41) | 124 (31) | |
| 1 chronic condition | 1005 (31) | 745 (32) | 384 (16) | |
| 2 chronic conditions | 415 (13) | 384 (16) | 81 (20) | |
| ≥3 chronic conditions | 228 (7) | 265 (11) | 65 (16) | |
| LUTS Treatments, n (%) | ||||
| α-antagonist | 286 (9) | 504 (22) | 135 (35) | <0.001 |
| 5α-reductase inhibitor | 60 (2) | 94 (4) | 19 (5) | <0.001 |
| Anti-cholinergic | 17 (1) | 41 (2) | 16 (4) | <0.001 |
| Self-reported BPH Surgery | 469 (15) | 321 (14) | 56 (14) | 0.66 |
AUASI American Urologic Association Symptom Index; n sample size; SD standard deviation; IADL instrumental activities of daily living; BPH benign prostatic hyperplasia
P values calculated using Chi-square tests for categorical variables and Kruskal Wallis test for continuous variables.
Patients who reported feeling like they “have a lot of energy” at least some of the time.
Short Form-12 Mental Health Component Summary ≤50
Teng 3MS <80
Cumulative number of the following chronic medical conditions: stroke, Parkinson’s disease, myocardial infarction, angina, chronic obstructive pulmonary disease, congestive heart failure, diabetes mellitus, osteoporosis, osteoarthritis, hyperthyroidism or hypothyroidism.