Table 2.

Association of American Urologic Association Symptom Index total score, storage subscore, and voiding subscore with frailty phenotype classification among 5979 men enrolled in MrOS.

	Multinomial Odds Ratio (95% Confidence Interval)
	Age and Site-Adjusted Model		Multivariable Model†
	Intermediate vs Robust	Frail vs Robust	Intermediate vs Robust	Frail vs Robust
Overall LUTS Severity (AUASI total score*)
None/Mild (0–7)	1.00	1.00	1.00	1.00
Moderate (8–19)	1.15 (1.02, 1.29)	1.55 (1.26, 1.90)	1.11 (0.99, 1.25)	1.41 (1.14, 1.74)
Severe (20–35)	1.46 (1.14, 1.85)	3.07 (2.19, 4.31)	1.35 (1.06, 1.73)	2.51 (1.76, 3.55)
AUASI storage subscore*
0–3	1.00	1.00	1.00	1.00
4–6	1.07 (0.94, 1.22)	1.25 (0.98, 1.59)	1.06 (0.93, 1.20)	1.17 (0.92, 1.50)
7–15	1.32 (1.15, 1.52)	2.39 (1.89, 3.02)	1.25 (1.08, 1.44)	2.02 (1.59, 2.57)
AUASI voiding subscore*
0–1	1.00	1.00	1.00	1.00
2–4	1.04 (0.91, 1.20)	1.10 (0.85, 1.42)	1.02 (0.89, 1.17)	1.05 (0.81, 1.37)
5–20	1.12 (0.99, 1.28)	1.71 (1.37, 2.14)	1.08 (0.95, 1.23)	1.53 (1.22, 1.93)

AUASI American Urologic Association Symptom Index; LUTS Lower Urinary Tract Symptoms

^*AUASI score range is 0 to 35 and equals the sum of 2 validated subscores based on symptom type: storage (urgency, frequency, nocturia) and voiding (intermittency, weak stream, straining, incomplete emptying). Higher score indicates more frequent symptoms. AUASI total score categorized using validated thresholds for none/mild (0–7), moderate (8–19), and severe (20–35) LUTS and AUASI subscores categorized into approximately equal thirds (tertiles) of the subscore distribution.

^†Multivariable multinomial regression model adjusted for study site, age, and self-reported history of cardiovascular disease (myocardial infarction or angina), diabetes, congestive heart failure, chronic obstructive pulmonary disease, or hypertension.