Table 3.

Multivariable-adjusted association of American Urologic Association Symptom Index total score, storage subscore, and voiding subscore with frailty phenotype components.

	Odds Ratio (95% Confidence Interval)
	Low Lean Mass	Weakness	Exhaustion	Slowness	Low Physical Activity
Overall LUTS Severity (AUASI total score*)
None/Mild (0–7)	1.00	1.00	1.00	1.00	1.00
Moderate (8–19)	0.98 (0.85, 1.12)	1.16 (1.02, 1.33)	2.02 (1.64, 2.50)	1.12 (0.97, 1.29)	1.19 (1.04, 1.37)
Severe (20–35)	1.05 (0.80, 1.36)	1.19 (0.93, 1.52)	4.37 (3.25, 5.86)	1.23 (0.95, 1.60)	1.41 (1.10, 1.80)
AUASI storage subscore*
0–3	1.00	1.00	1.00	1.00	1.00
4–6	1.03 (0.88, 1.20)	1.03 (0.89, 1.20)	1.53 (1.20, 1.97)	1.09 (0.93, 1.28)	1.07 (0.92, 1.26)
7–15	0.98 (0.83, 1.16)	1.35 (1.16, 1.58)	2.74 (2.17, 3.47)	1.32 (1.11, 1.55)	1.31 (1.12, 1.54)
AUASI voiding subscore*
0–1	1.00	1.00	1.00	1.00	1.00
2–4	0.87 (0.73, 1.03)	1.07 (0.92, 1.26)	1.38 (1.06, 1.82)	1.01 (0.85, 1.20)	1.04 (0.88, 1.23)
5–20	1.05 (0.90, 1.22)	1.05 (0.91, 1.22)	2.59 (2.06, 3.26)	0.99 (0.85, 1.16)	1.22 (1.05, 1.42)

AUASI American Urologic Association Symptom Index; LUTS Lower Urinary Tract Symptoms

^*AUASI score range is 0 to 35 and equals the sum of 2 validated subscores based on symptom type: storage (urgency, frequency, nocturia) and voiding (intermittency, weak stream, straining, incomplete emptying). Higher score indicates more frequent symptoms. AUASI total score categorized using validated thresholds for none/mild (0–7), moderate (8–19), and severe (20–35) LUTS and AUASI subscores categorized into approximately equal thirds (tertiles) of the subscore distribution.

^†Multivariable logistic regression model adjusted for study site, age, and self-reported history of cardiovascular disease (myocardial infarction or angina), diabetes, congestive heart failure, chronic obstructive pulmonary disease, or hypertension.