Extended Data Fig. 1. Hexosamine-related metabolic pathways are associated with KL mouse tumors.

a, GSEA between KL tumors and adjacent lungs returned “Amino sugar and nucleotide metabolism”, “Fructose and mannose metabolism”, and “Oxidative Phosphorylation” as the top ranked metabolic gene ontology terms from KEGG database. Enrichment statistics include nominal p value and nominal enrichment score (NES). b, The leading-edge genes of “Amino sugar and nucleotide sugar metabolism” (left) and “Fructose and mannose metabolism” (right) are in Extended Data Fig. 3a. The leading-edge genes of “Oxidative Phosphorylation” (not displayed here) are in Supplementary Table 3. c, The leading-edge genes of “Amino sugar and nucleotide sugar metabolism”, “Fructose and mannose metabolism” and “O-Glycan biosynthesis” in Fig. 1a.