Table 2.

Genes involved in ARHR2, osteoporosis, and OPLL and their associated fold changes in 10 week and 23 week Enpp1^asj/asj mice as compared to WT. Statistical significance after FDR correction (< 0.05) are highlighted in blue.

Cohort	Gene	Fold change	Padj
ARHR2
10-week	Dmp1	1.5	0.21
	Enpp1	1.8	1.3E–03
	Fgf23	6.0	5.1E–12
	Gcnt4	1.6	0.45
	Spp1	1.5	0.27
	Vdr	1.4	0.02
23-week	Alpl	−1.6	0.07
	Col12a1	−1.7	7.1E–04
	Col6a1	−1.4	0.01
	Col6a2	−1.5	2.2E–03
	Col6a3	−1.4	2.6E–03
	Enpp1	1.2	0.22
	Fgf23	2.6	0.03
	Hacd1	−1.4	0.05
	Mmp2	−1.4	2.4E–03
	Spp1	1.4	0.22
Osteoporosis
10-week	Mepe	−1.5	0.37
	Sost	−1.6	0.19
	Spp1	1.5	0.27
	Vdr	1.4	0.02
23-week	Alpl	−1.6	0.07
	Esrl	−1.3	0.06
	Mepe	−1.4	0.38
	Sost	−1.6	0.42
	Sp7	−1.4	0.09
	Spp1	1.4	0.22
	Tgfb3	−1.4	0.08
	Wnt16	−1.9	1.3E-04
	Wnt10b	−1.8	<0.01
	Lrp1	−1.2	<0.05
OPLL
10-week	Ace	−1.2	0.33
	Enpp1	1.8	1.3E-03
	Vdr	1.4	0.02
23-week	Acvr1	−1.4	0.03
	Adamts2	−1.2	0.02
	Antxr1	−1.4	3.8E-03
	C1s1	−1.3	0.03
	Cdon	−1.5	4.2E–03
	Col12a1	−1.7	7.1E–04
	Col6a1	−1.7	0.01
	Col3a1	−1.8	0.03
	Col5a1	−1.4	0.02
	Col6a1	−1.4	0.01
	Col6a2	−1.5	2.2E–03
	Col6a3	−1.4	2.6E–03
	Col8a2	−1.8	2.5E–05
	Dchs1	−1.3	0.01
	Ddr2	−1.4	3.8E–04
	Dlx5	−1.7	4.1E–04
	Dnmt3a	−1.2	2.6E–03
	Esr1	−1.3	0.06
	Fat4	−1.4	0.01
	Fbn1	−1.4	0.03
	Fgfr1	−1.3	0.08
	Fgfr2	−1.3	0.03
	Gpc3	−1.5	0.02
	Hspb8	−1.6	0.04
	Hspg2	−1.3	0.02
	Itgb6	−1.7	0.02
	Klhl41	−1.7	0.01
	Mylk	−1.3	3.3E-05
	Pcolce	−1.3	0.01
	Pcolce2	−1.9	0.01
	Prkg1	−1.6	0.04
	Ptch1	−1.2	0.04
	Ror2	−1.6	0.03
	Tgfb3	−1.4	0.08
	Tnxb	−1.8	2.9E–03