Table 4.
Stratum | No. at Risk | No. of Events | Model 1 | Model 2 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HR (95%CI) | p | Multipl. Interaction p | df | X2 | HR (95%CI) | p | Multipl. Interaction p | df | X2 | |||
FDG-PET− / Depr. & Irritab.− | 892 | 76 | 1.00 (ref. group) | 0.039 | 1.00 (ref. group) | 0.033 | ||||||
FDG-PET+ / Depr. & Irritab.− | 323 | 90 | 2.50 (1.83, 3.42) | <0.001 | 1 | 33.23 | 2.36 (1.72, 3.23) | <0.001 | 1 | 28.39 | ||
FDG-PET− / Depr. & Irritab.+ | 23 | 3 | 3.68 (1.14, 11.9) | 0.029 | 1 | 4.74 | 3.38 (1.04, 10.9) | 0.042 | 1 | 4.13 | ||
FDG-PET+ / Depr. & Irritab.+ | 13 | 4 | 1.63 (0.51, 5.20) | 0.41 | 1 | 0.68 | 1.33 (0.41,4.28) | 0.63 | 1 | 0.23 | ||
FDG-PET− / Depr. & Anxiety− | 899 | 77 | 1.00 (ref. group) | 0.36 | 1.00 (ref. group) | 0.40 | ||||||
FDG-PET+ / Depr. & Anxiety− | 325 | 90 | 2.42 (1.77, 3.31) | <0.001 | 1 | 30.92 | 2.27 (1.66, 3.12) | <0.001 | 1 | 25.95 | ||
FDG-PET− / Depr. & Anxiety+ | 16 | 2 | 2.50 (0.61, 10.3) | 0.20 | 1 | 1.61 | 2.17 (0.53, 8.96) | 0.28 | 1 | 1.15 | ||
FDG-PET+ / Depr. & Anxiety+ | 11 | 4 | 2.68 (0.97, 7.40) | 0.06 | 1 | 3.62 | 2.33 (0.84, 6.44) | 0.10 | 1 | 2.67 | ||
FDG-PET− / Depr. & Apathy− | 900 | 74 | 1.00 (ref. group) | 0.32 | 1.00 (ref. group) | 0.25 | ||||||
FDG-PET+ / Depr. & Apathy− | 326 | 88 | 2.44 (1.78, 3.34) | <0.001 | 1 | 30.59 | 2.30 (1.67, 3.17) | <0.001 | 1 | 26.09 | ||
FDG-PET− / Depr. & Apathy+ | 15 | 5 | 7.96 (3.16, 20.0) | <0.001 | 1 | 19.35 | 6.98 (2.75, 17.7) | <0.001 | 1 | 16.77 | ||
FDG-PET+ / Depr. & Apathy+ | 10 | 6 | 9.95 (3.90, 25.3) | <0.001 | 1 | 23.17 | 7.41 (2.81, 19.5) | <0.001 | 1 | 16.40 | ||
FDG-PET− / Anxiety & Irritab.− | 902 | 78 | 1.00 (ref. group) | 0.53 | 1.00 (ref. group) | 0.55 | ||||||
FDG-PET+ / Anxiety & Irritab.− | 327 | 91 | 2.44 (1.79, 3.33) | <0.001 | 1 | 31.65 | 2.29 (1.67, 3.13) | <0.001 | 1 | 26.61 | ||
FDG-PET− / Anxiety & Irritab.+ | 13 | 1 | 1.57 (0.22, 11.4) | 0.65 | 1 | 0.20 | 1.38 (0.19, 10.0) | 0.75 | 1 | 0.10 | ||
FDG-PET+ / Anxiety & Irritab.+ | 9 | 3 | 1.84 (0.57, 5.88) | 0.30 | 1 | 1.05 | 1.57 (0.49, 5.02) | 0.45 | 1 | 0.57 | ||
FDG-PET− / Depr. & Nightt. beh.− | 891 | 74 | 1.00 (ref. group) | 0.07 | 1.00 (ref. group) | 0.06 | ||||||
FDG-PET+ / Depr. & Nightt. beh.− | 322 | 89 | 2.47 (1.80, 3.38) | <0.001 | 1 | 31.31 | 2.33 (1.70, 3.21) | <0.001 | 1 | 27.04 | ||
FDG-PET− / Depr. & Nightt. beh.+ | 13 | 3 | 4.46 (1.38, 14.4) | 0.013 | 1 | 6.24 | 4.00 (1.23, 13.0) | 0.021 | 1 | 5.34 | ||
FDG-PET+ / Depr. & Nightt. beh.+ | 9 | 2 | 1.99 (0.48, 8.20) | 0.34 | 1 | 0.90 | 1.63 (0.39, 6.81) | 0.50 | 1 | 0.45 | ||
FDG-PET− / Apathy & Irritab.− | 901 | 76 | 1.00 (ref. group) | 0.36 | 1.00 (ref. group) | 0.33 | ||||||
FDG-PET+ / Apathy & Irritab.− | 330 | 90 | 2.43 (1.78, 3.32) | <0.001 | 1 | 31.06 | 2.28 (1.67, 3.13) | <0.001 | 1 | 26.23 | ||
FDG-PET− /Apathy & Irritab.+ | 14 | 3 | 4.40 (1.37, 14.2) | 0.013 | 1 | 6.16 | 3.93 (1.22, 12.7) | 0.022 | 1 | 5.24 | ||
FDG-PET+ / Apathy & Irritab.+ | 6 | 4 | 4.98 (1.54, 16.0) | 0.007 | 1 | 7.23 | 3.95 (1.21, 12.9) | 0.023 | 1 | 5.20 |
Abbreviations: FDG-PET+ = Participants with regional brain glucose hypometabolism; FDG-PET− = Participants with normal regional brain glucose metabolism; HR = Hazard ratio; 95% CI = 95% confidence interval; p indicates significance; df = degree of freedom; X2 = Wald Chi-squared; ref. group = Reference group. Results based on Cox proportional hazards models. Wald Chi-squared test was used to test for multiplicative interaction (df = 1). Model 1 adjusted for age (as the time scale), sex, education, and APOE ε4 status. Model 2 additionally adjusted for medical comorbidity and antidepressant medication intake.