Scheme 7.
Synthesis analogues with cyclic alkyl chain. Reagents and conditions: (a) THF, reflux; (b) HClconc, EtOH, reflux; (c) NaBH4, TFA, DCM, 0 °C to rt; (d) H2 (80 psi), Pd/C (cat.), EtOH; (e) 48j, DCM, rt
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