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Synthesis of analogues with substitutions at monophenyl “head” moiety. Reagents and conditions: (a) triphosgene, DCM, rt; (b) 29a, DCM, 0 °C to 32 °C; (c) H2N-NH2, Raney-nickel, ethanol, 50 °C; (d) acetic anhydride, DCM. (e) SOCl2, MeOH, reflux; (f) benzyl bromide, K2CO3, DMF, 100 °C; (g) triphosgene, DCM, r.t; (h) 29a, DCM, 0 °C to 32 °C; (i) Pd/C, NaBH4, MeOH.
