Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of analogs with substitution at diphenyl (“tail”) moiety. Reagents and conditions: (a) 48a, 48j-k, DCM, 0 °C to 32 °C; (b) H2N-NH2, Raney nickel, ethanol, 50 °C; (c) acetic anhydride, DCM; (d) NaH, 1, 4-dibromobutane, THF, rt; (e) NH4OH, dioxane, 100 °C; (f) 48a, 48b, 48j, 48n, 48q, DCM, 0 °C to 32 °C; (g) LiAlH4, 1N HCl, THF; (h) CBr4, Ph3P, DCM, 0 °C to rt; (i) 48j, DCM, 0 °C to 32 °C.
