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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Eur J Med Chem. 2020 Sep 24;209:112866. doi: 10.1016/j.ejmech.2020.112866

Table 1.

In vitro cytotoxic activity of analogs with the mono-substitution at the “head” moiety.

graphic file with name nihms-1636352-t0020.jpg
R MDA-MB-231 aIC50 (μM) R MDA-MB-231 aIC50 (μM)
4a graphic file with name nihms-1636352-t0021.jpg 7.68 ± 0.21 4g graphic file with name nihms-1636352-t0022.jpg 3.38 ± 0.08
4b graphic file with name nihms-1636352-t0023.jpg 11.79 ± 0.40 4h graphic file with name nihms-1636352-t0024.jpg 2.78 ± 0.09
4c graphic file with name nihms-1636352-t0025.jpg >20.00 4i graphic file with name nihms-1636352-t0026.jpg 5.07 ± 0.33
4d graphic file with name nihms-1636352-t0027.jpg 6.47 ± 0.84 4j graphic file with name nihms-1636352-t0028.jpg 3.79 ± 0.22
4e graphic file with name nihms-1636352-t0029.jpg >20.0 4k graphic file with name nihms-1636352-t0030.jpg >20.0
4f >20.0
a

Data are expressed as the mean ± SEM of three independent experiments, each performed in a quartet.