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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Eur J Med Chem. 2020 Sep 24;209:112866. doi: 10.1016/j.ejmech.2020.112866

Table 2.

In vitro cytotoxic activity of analogs with the di-substitution at the “head” moiety.

graphic file with name nihms-1636352-t0031.jpg
R MDA-MB-231 aIC50 (μM) R MDA-MB-231 aIC50 (μM)
4l graphic file with name nihms-1636352-t0032.jpg 3.15 ± 0.11 4r graphic file with name nihms-1636352-t0033.jpg >20.0
4m graphic file with name nihms-1636352-t0034.jpg 4.06 ± 0.74 4s graphic file with name nihms-1636352-t0035.jpg >20.0
4n graphic file with name nihms-1636352-t0036.jpg 9.24 ± 0.29 4t graphic file with name nihms-1636352-t0037.jpg >20.0
4o graphic file with name nihms-1636352-t0038.jpg 9.12 ± 0.43 4u graphic file with name nihms-1636352-t0039.jpg >20.0
4p graphic file with name nihms-1636352-t0040.jpg 3.47 ± 0.14 4v graphic file with name nihms-1636352-t0041.jpg 4.43 ± 0.23
4q graphic file with name nihms-1636352-t0042.jpg 4.55 ± 0.12 4x graphic file with name nihms-1636352-t0043.jpg >20.0
a

Data are expressed as the mean ± SEM of three independent experiments, each performed in a quartet.