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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Eur J Med Chem. 2020 Sep 24;209:112866. doi: 10.1016/j.ejmech.2020.112866

Table 3.

In vitro cytotoxic activity of analogs with the modifications at the “tail” di-phenyl moiety.

graphic file with name nihms-1636352-t0044.jpg
R1 R2 MDA-MB-231 aIC50 (μM)
4l graphic file with name nihms-1636352-t0045.jpg 4-Cl, 3-CF3 3.15 ± 0.11
8a graphic file with name nihms-1636352-t0046.jpg 4-Cl, 3-CF3 2.51 ± 0.09
8b 4-Cl 17.93 ± 0.37
8c graphic file with name nihms-1636352-t0047.jpg 4-Cl, 3-CF3 3.30 ± 0.32
8d 4-Cl, 3-NO2 3.99 ± 0.44
8e graphic file with name nihms-1636352-t0048.jpg 4-Cl, 3-CF3 1.69 ± 0.11
8f graphic file with name nihms-1636352-t0049.jpg 4-Cl, 3-CF3 5.72 ± 0.26
8g graphic file with name nihms-1636352-t0050.jpg 4-Cl, 3-CF3 1.23 ± 0.20
8h graphic file with name nihms-1636352-t0051.jpg 4-Cl, 3-CF3 12.20 ± 0.59
8i graphic file with name nihms-1636352-t0052.jpg 4-Cl, 3-CF3 >20.0
9a graphic file with name nihms-1636352-t0053.jpg 4-Cl >20.0
9b 4-I > 20.0
9c 4-Cl, 3-CF3 5.04 ± 0.14
9d 4-CH3, 3-CH3 >20.0
9e 4-Br, 2-I > 20.0
10 4-Cl, 3-CF3 5.44 ± 0.59
a

Data are expressed as the mean ± SEM of three independent experiments, each performed in a quartet.