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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Eur J Med Chem. 2020 Sep 24;209:112866. doi: 10.1016/j.ejmech.2020.112866

Table 4.

In vitro inhibitory activity of analogs with modifications in the linker part.

graphic file with name nihms-1636352-t0054.jpg
graphic file with name nihms-1636352-t0055.jpg MDA-MB-231 aIC50 (μM) graphic file with name nihms-1636352-t0056.jpg MDA-MB-231 aIC50 (μM)
4l 3.15 ± 0.11 15 > 20.0
11a 3.50 ± 0.08 16 11.44 ± 0.40
11b graphic file with name nihms-1636352-t0057.jpg 2.57 ± 0.07 17 graphic file with name nihms-1636352-t0058.jpg 11.71 ± 0.38
12 graphic file with name nihms-1636352-t0059.jpg 3.66 ± 0.12 18 graphic file with name nihms-1636352-t0060.jpg 5.65 ± 0.43
13 graphic file with name nihms-1636352-t0061.jpg 4.58 ± 0.25 19a graphic file with name nihms-1636352-t0062.jpg 11.41 ± 0.32
14 graphic file with name nihms-1636352-t0063.jpg 6.02 ± 0.09 19b graphic file with name nihms-1636352-t0064.jpg 4.84 ± 0.17
a

Data are expressed as the mean ± SEM of three independent experiments, each performed in quartet.