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. 2020 Dec 3;8:602009. doi: 10.3389/fbioe.2020.602009

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Copyright © 2020 Assunção, Dehghan-Baniani, Yiu, Später, Beyer and Blocki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD-ECM applications in fundamental research, pathophysiological studies and renegerative medicine. The ease with which CD-ECM can be modified, makes it the ideal platform to study detailed ECM mechanisms or the role of cellular niches under physiological and pathophysiological conditions. Specialized engineered cellular niches can be further utilized to improve cellular functions in vitro, such as stemness. In TERM, CD-ECMs can be created with specific mechanical and biological properties to be used on their own (i.e., as vascular grafts) or to enhance the performance of (semi-) synthetic biomaterials.