TABLE 1.

Authorized indications in Europe and the United States.

Indication	Loading dose	Maintenance dose	Duration
Malaria prophylaxis	800 mg (if not possible to start before exposure)	400 mg/week (1–2 weeks before entering the malaria area)	For 4–8 weeks after leaving the area
Malaria treatment	800 mg followed by 400 mg after 6–8 h	400 mg/day for 2 subsequent days	3 days
—	Single dose of 800 mg (for P. Vivax and P. Falciparum)	—	—
	400 mg/day	200 mg/day	Until failure
—	400–600 mg/day for 6–8 weeks	200–400 mg/day, later 200 mg every other day	Until failure
—	400–600 mg/day	200 mg or 400 mg/day	Until failure
—	—	200 or 400 mg/day	Until failure
—	400–600 mg/day for 2 weeks	200–400 mg/week	Until failure
—	400–600 mg/day for 4–6 weeks	200–400 mg/day	Until failure
—	400–600 mg/dayas loading dose	200–400 mg/day	Until failure
Discoid and systemic lupus erythematosus	400–600 mg/day for 2 weeks	200–400 mg/week	Until failure
—	400–600 mg/day for a few weeks	200–400 mg/day	Until failure
—	400 mg daily until no further improvement is observed	200 mg/day	Until failure
—	—	200 or 400 mg/day	Until failure
—	400–600 mg/day	200 or 400 mg/day	Until failure
—	400–600 mg/day for several weeks if necessary	—	Until failure
—	400–800 mg/day	200–400 mg/day	Until failure
—	400 mg/day	200–400 mg/day	Based on patient’s response
—	400–600 mg/day for 4–6 weeks	200–400 mg/day	Until failure
—	200–400 mg/day; up to 600 mg/day if no response after 1–2 months	Reduction to 100 mg/day for several months, or 200–300 mg/week over several years	Until failure
Photodermatosis	400 mg/day until no further improvement is observed	200 mg/day	—
—	—	400 mg/day	For period of maximum exposure to sunlight
—	—	200 or 400 mg/day	—
—	400–600 mg daily for 4–6 weeks	200–400 mg/day	—
—	—	400–600 mg/day for 7 days before sun exposure	15 days