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. Author manuscript; available in PMC: 2021 Jun 15.
Published in final edited form as: Cancer Res. 2020 Nov 9;80(24):5543–5553. doi: 10.1158/0008-5472.CAN-20-2379

Figure 5. Most genes downregulated upon loss of Gcn5 are up regulated upon Myc overexpression.

Figure 5.

A. Heat Map of differentially expressed genes regulated by Myc. B. RNA-seq values and qRT-PCR validation of genes regulated by Myc. (n=3) All p-values determined by unpaired Student’s t-test. Significant P-value was <0.05. C. Immunoblot of Myc expression relative to Gapdh D. Model of Gcn5 partnership with the Myc oncoprotein in B cell lymphoma. Gcn5 acts as a transcriptional coactivator in the transcription of Myc target genes that promote both lymphomagenesis and lymphoma cell survival.