Age |
59±5 |
0 |
59±5 |
0 |
0.28 |
Race |
|
4% |
|
3% |
<0.001 |
White |
68% |
|
72% |
|
|
Black |
24% |
|
21% |
|
|
Other |
4% |
|
3% |
|
|
Female sex |
7% |
0 |
11% |
0 |
<0.001 |
Died during follow-up |
10% |
0 |
16% |
0 |
<0.001 |
VACS Index Score 2.0 (mean±SD) |
35±10 |
31% |
37±11 |
22% |
<0.001 |
Wrist, hip, upper arm fracture |
3% |
0 |
19% |
0 |
<0.001 |
Hip fracture |
0.1% |
0 |
1.6% |
0 |
<0.001 |
Body mass index |
|
21% |
|
14% |
<0.001 |
<18.5 |
0.7% |
|
0.9% |
|
|
18.5 – 25 |
13% |
|
15% |
|
|
25 – 30 |
26% |
|
26% |
|
|
>30 |
40% |
|
44% |
|
|
Smoking |
|
2% |
|
1% |
<0.001 |
Never |
27% |
|
25% |
|
|
Current |
46% |
|
50% |
|
|
Past |
25% |
|
24% |
|
|
Pain score in the prior six-month period (mean±SD) |
3±3 |
34% |
4±3 |
26% |
<0.001 |
Physical comorbidity count (mean±SD) |
2±2 |
0 |
3±3 |
0 |
<0.001 |
Mental health comorbidity count (mean±SD) |
0.4±0.7 |
0 |
0.7±0.9 |
0 |
<0.001 |
Drug use/abuse |
11% |
0 |
20% |
0 |
<0.001 |
Hazardous alcohol use |
29% |
50% |
17% |
48% |
<0.001 |
Diagnosis of alcohol use/abuse |
27% |
0 |
15% |
0 |
<0.001 |
Cardiovascular medications |
|
0 |
|
0 |
|
Antithrombotics |
16% |
|
25% |
|
<0.001 |
Antiarrhythmics |
10% |
|
20% |
|
<0.001 |
Antihypertensives |
70% |
|
79% |
|
<0.001 |
Nitrates |
11% |
|
16% |
|
<0.001 |
Mental health medications |
|
0 |
|
0 |
|
SSRI |
32% |
|
46% |
|
<0.001 |
SNRI |
10% |
|
17% |
|
<0.001 |
Atypical antidepressants |
33% |
|
48% |
|
<0.001 |
TCA |
9% |
|
15% |
|
<0.001 |
Antipsychotics |
14% |
|
24% |
|
<0.001 |
Other CNS-active medications |
|
0 |
|
0 |
|
Benzodiazepines |
23% |
|
37% |
|
<0.001 |
Muscle relaxants |
30% |
|
47% |
|
<0.001 |
Opioids |
60% |
|
83% |
|
<0.001 |
Anticonvulsants |
35% |
|
56% |
|
<0.001 |
Antihistamines |
38% |
|
54% |
|
<0.001 |
Hypoglycemics |
23% |
0 |
29% |
0 |
<0.001 |
Proton pump inhibitors |
44% |
0 |
61% |
0 |
<0.001 |
Medication count |
8±6 |
0 |
11±8 |
0 |
<0.001 |