Table 2.

Regions showing significant amplitude of low-frequency fluctuation (ALFF) differences among the four groups of healthy control, smokers, internet gaming disorder (IGD), IGD-Smoking individuals (p < 0.05, FWE-corrected).

Identified brain regions	Peak coordinates (MNI)			Side	Peak F	Cluster size (voxels)
	X	Y	Z
Medial pre-frontal cortex (i.e., orbital frontal cortex and anterior cingulate cortex)/ventral striatum	15	33	−15	R	36.81	863
Cerebellar and visual-related regions (i.e., calcarine, cuneus, and lingual gyrus)	−12	−51	−15	B	28.39	502
Inferior temporal gyrus	−42	−33	−21	L	25.28	71

Analysis of covariance (ANCOVA) controlling for age, years of education, and mean frame-wise displacement was performed to investigate the interaction between smoking and IGD on ALFF.