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. 2020 Dec 3;11:587663. doi: 10.3389/fphar.2020.587663

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Copyright © 2020 Wang, Long, Huang, Zhang, Xie, Chen, Liu, Xiong and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Research conducted in this study. This study was divided into three main parts: 1) verification of the therapeutic effects of BSHX decoction in DN mice; 2) ascertainment of the components and potential active compounds in BSHX decoction using UPLC-Q-TOF-MS; and 3) exploration of the mechanism underlying BSHX decoction activity using IHC, western blot, and RT-qPCR to detect podocyte EMT markers and factors involved in Rac1/PAK1/p38MAPK signaling.