TABLE 5.
Antimicrobial target proteins used in the docking exercise.
Protein name | PDB Id | Classification | Organism | Method |
C-1027 | 1hzl | Antibiotic | Streptomyces globisporus | Solution NMR |
Tyrosine aminomutase | 3kdy | Lyase | Streptomyces globisporus | X-ray diffraction |
50s ribosomal protein l32 | 6qul | Antibiotic | Escherichia coli | Electron microscopy |
Carbapenam synthetase | 1q15 | Biosynthetic protein | Pectobacterium carotovorum | X-ray diffraction |
Iron(3 +)-hydroxamate-binding protein fhud | 1esz | Metal transport | Escherichia coli | X-ray diffraction |
Fhua | 1by3 | Membrane protein | Escherichia coli | X-ray diffraction |
Neocarzinostatin | 1nco | Antibacterial and antitumor protein | Streptomyces carzinostaticus | X-ray diffraction |
Protein phzg | 1ty9 | Oxidoreductase | Pseudomonas fluorescens | X-ray diffraction |
Lipocalins | 1nyc | Hydrolase inhibitor | Escherichia coli | X-ray diffraction |
D-alanyl-d-alanine carboxypeptidase | 6osu | Hydrolase | Francisella tularensis subsp. Tularensis schu s4 | X-ray diffraction |
Beta-hexosaminidase | 4g6c | Hydrolase | Burkholderia cenocepacia j2315 | X-ray diffraction |
Mexa of the multidrug transporter | 1vf7 | Membrane protein | Pseudomonas aeruginosa | X-ray diffraction |
S/t protein kinase pkng | 4y0x | Transferase | Mycobacterium tuberculosis h37rv | X-ray diffraction |
Bacterial 45srbga ribosomal particle class a | 6pvk | Ribosome | Bacillus subtilis | Electron microscopy |
Neocarzinostatin | 1nco | Antibacterial and antitumor protein | Streptomyces carzinostaticus | X-ray diffraction |
Carbapenam | 4oj8 | Oxidoreductase | Pectobacterium carotovorum subsp. Carotovorum | X-ray diffraction |
Vancosaminyl transferase | 1rrv | Transferase/antibiotic | Amycolatopsis orientalis | X-ray diffraction |