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. 2020 Oct 13;203(1):32–40. doi: 10.1111/cei.13521

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© 2020 The Authors. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig. 4 — Relationship between anti‐dsDNA immunoglobulin (Ig)M autoantibody levels and anti‐F4, anti‐citrate synthase (CS) IgM natural autoantibody titers in systemic lupus erythematosus (SLE) patients (n _SLE = 92). Qualitative (positive, negative) anti‐dsDNA IgM results were compared to quantitative anti‐DNA topoisomerase I F4 fragment (anti‐F4) IgM and anti‐CS IgM results (expressed in arbitrary units, based on our in‐house standard), using Mann–Whitney U analysis. The levels of anti‐F4 and anti‐CS IgM natural antibodies were significantly elevated in anti‐dsDNA IgM‐positive compared to anti‐dsDNA IgM‐negative SLE patients. Boxes show interquartile ranges (IQR); whiskers indicate lowest and highest values; horizontal lines represent medians.