Fig. 2.

Interleukin (IL)‐8‐dependent bioluminescence emission in mice with PAO1 acute lung infection treated with Marimastat and Ilomastat. Photon emission was measured before treatment with matrix metalloprotease inhibitors (MMPIs) (indicated as 0 h) and after 4 and 24 h. Photon emission is expressed as total flux (p/s) (left panels) and as folds of induction (FOI) versus baseline (right panels) in wild‐type (WT) (a,b) and knock‐out (KO) (c,d) mice. Each value represents the mean ± standard error of the mean (s.e.m.) of eight animals (biological replicates) per group; *P < 0·05, ***P < 0·001.