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. 2020 Dec 16;10:22058. doi: 10.1038/s41598-020-79151-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Box plots illustrating the distribution of the rates of changes in NFLD-angle (degree/year), VD (%/year), and deMv-angle (degree/year). Rates of changes in NFLD-angle and deMv-angle are adjusted by IOP, and the rate of VD change is adjusted by IOP and SSI. The medians are represented by horizontal lines in the white boxes. Boxes represent the interquartile range between the first and third quartiles. **P-value < 0.001.