Fig. 4. Stacked bar chart showing the results from variance decomposition of plasma abundances of 106 aptamers targeting candidate proteins.

For each candidate protein a model was fitted to decompose the variance in plasma levels including all 16 factors noted in the legend. These analyses were done based on 8006 participants with complete data. cis/trans-GRS = weighted genetic risk score based on all single nucleotide polymorphisms associated with the aptamer of interest acting in cis and trans, respectively. BMI (body mass index), WHR (waist-to-hip ratio), HDL (high-density lipoprotein), LDL (low-density lipoprotein), eGFR (estimated glomerular filtration rate), ALT (alanine amino transaminase), and BP (blood pressure).