Skip to main content
. 2020 Dec 16;11:6408. doi: 10.1038/s41467-020-20231-y

Fig. 6. SPAs inhibit a range of pathologies involving extracellular histones.

Fig. 6

a Survival of rats (n = 8 per group) subjected to cecal ligation and puncture (CLP) and receiving saline (Control), CBS, or MTS. P values obtained with survival analysis log-rank (Mantel–Cox) test. b Kidney and liver damage in CLP rats, as measured by ALT and creatinine blood levels (n = 4–8/group, blood could not be collected or was clotted from some rats). c Effect of CBS and MTS (n = 6–12/group) on cardiac IRI in rats, with the area at risk (AAR) in left ventricle (LV), microvascular obstruction (MVO), and infarct area being measured. d Effect of mCBS and MTS on a skin flap model of IRI in rats (n = 3–5/group), with representative photos shown (skin flap reduced to 25% normal size). Data are presented as mean ± s.e.m. and analyzed by one-way ANOVA with Dunnett’s correction for multiple comparisons. Source data are provided as a Source Data File.