TABLE 1.
Demographics, clinical information, and neurocognitive performance.
| Variable | Control (n = 46) | GDS normal (n = 55) | GDS impaired (n = 36) | P-value |
| Age (mean ± SD) | 34.4 ± 6.7 | 32.0 ± 7.2 | 30.8 ± 7.1 | 0.057a |
| Male, n (%) | 42 (91.3%) | 54 (98.2%) | 36 (100.0%) | 0.089d |
| Education years (mean ± SD) | / | 13.0 ± 3.7 | 14.3 ± 2.7 | 0.060b |
| CD4 + T (mean ± SD) | / | 473.9 ± 233.3 | 496.2 ± 208.3 | 0.643b |
| CD4/CD8 (mean ± SD) | / | 0.6 ± 0.4 | 0.6 ± 0.5 | 0.982b |
| TND, n (%) | / | 30 (85.7%) | 18 (81.8%) | 0.722d |
| BMI (mean ± SD) | / | 21.1 ± 2.7 | 22.4 ± 2.6 | 0.031b |
| Hepatitis B virus infection, n (%) | / | 13 (26.5%) | 9 (26.5%) | 1.000c |
| Hepatitis C virus infection, n (%) | / | 1 (2.0%) | 0 (0.0%) | 1.000d |
| Syphilis, n (%) | / | 19 (34.5%) | 16 (44.4%) | 0.383c |
| TIV (mean ± SD) | 1,507.7 ± 132.8 | 1,528.2 ± 120.1 | 1,553.0 ± 100.9 | 0.240a |
| Neurocognitive performance T scores (mean ± SD) | ||||
| Speed of information processing | / | 48.4 ± 7.2 | 40.8 ± 9.5 | < 0.001b |
| Memory (learning and recall) | / | 46.8 ± 6.5 | 39.1 ± 7.7 | < 0.001b |
| Abstraction/executive | / | 58.4 ± 9.1 | 51.9 ± 8.6 | 0.001b |
| Attention/working memory | / | 44.8 ± 7.2 | 38.2 ± 6.9 | < 0.001b |
| Fine motor skills | / | 48.4 ± 7.7 | 41.2 ± 11.8 | 0.001b |
| verbal and language | / | 48.7 ± 7.0 | 39.8 ± 9.6 | < 0.001b |
| GDS | / | 0.1 ± 0.1 | 0.8 ± 0.8 | < 0.001b |
TND, virus not detectable; BMI, body mass index; TIV, total intracranial volume; GDS, global deficit score.P-value for comparison among three groups (age, male%, TIV) and between GDS normal and GDS impaired subgroups.Statistical tests including: aone-way ANOVA; bt-test; cchi-square test; dFisher’s exact test.