Table 3.
FUT2 (rs601338) and ABO (rs505922) main and stratified effects in the COPSACsevere study (discovery), and the COPSAC birth cohorts (replication).
| Discovery (COPSACsevere) | ||||
|---|---|---|---|---|
| Gene | Analysis | OR [95% CI] | P value | Cases/controls |
| FUT2 | Main effect | 1.17 [1.07–1.29] | 0.001 | 1204/5328 |
| ABO = TT | 0.94 [0.81–0.10] | 0.45 | 410/2199 | |
| ABO = TC | 1.29 [1.13–1.48] | 2.0 × 10−4 | 623/2435 | |
| ABO = CC | 1.54 [1.18–2.02] | 0.001 | 171/694 | |
| ABO | Main effect | 1.16 [1.05–1.27] | 0.002 | 1204/5328 |
| FUT2 = AA | 0.83 [0.65–1.05] | 0.12 | 194/1095 | |
| FUT2 = AG | 1.12 [0.98–1.28] | 0.10 | 612/2624 | |
| FUT2 = GG | 1.43 [1.21–1.69] | 2.2 × 10−5 | 398/1609 | |
| FUT2 × ABO | Interaction | 1.29 [1.12–1.48] | 3.2 × 10−4 | 1204/5328 |
| Replication (COPSAC birth cohorts) | ||||
| FUT2 | Main effect | 1.31 [1.04; 1.67] | 0.02 | 191/727 |
| ABO = TT | 0.99 [0.67; 1.47] | 0.96 | 64/317 | |
| ABO = TC | 1.38 [0.99; 1.94] | 0.06 | 103/327 | |
| ABO = CC | 2.44 [1.20; 5.30] | 0.02 | 24/83 | |
| ABO | Main effect | 1.27 [1.00; 1.62] | 0.05 | 191/727 |
| FUT2 = AA | 0.94 [0.49; 1.73] | 0.84 | 27/142 | |
| FUT2 = AG | 1.10 [0.78; 1.55] | 0.57 | 93/367 | |
| FUT2 = GG | 1.93 [1.26; 3.00] | 0.003 | 71/218 | |
| FUT2 × ABO | Interaction | 1.50 [1.05; 2.17] | 0.03 | 191/727 |
| Risk score | 2.82 [1.56; 5.10] | 5.7 × 10−4 | 191/727 | |
The logistic regression models were adjusted for ten principal components and sex for the discovery and for cohort status and sex for the replication. The reported P values are not corrected for multiple comparisons.
P < 0.05 is in bold.