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. 2020 Dec 3;8:601953. doi: 10.3389/fcell.2020.601953

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Copyright © 2020 Wang, Xu, Xie, Hu, Jiang, Hu, Ding, Xiao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SIRT2 and TFEB are down-regulated in human NSCLC tissues and positively correlated with overall survival in TCGA database. (A,B) The expression of SIRT2 in lung adenocarcinoma (LUAD) patients (t = 483, n = 347) and the overall survival (OS) curves of SIRT2^high (n = 239) and SIRT2^low (n = 239) NSCLC patients. (C) Total protein was extracted from human NSCLC tissues (n = 40), SIRT2 was detected by western blot, the upper panel shows SIRT2 expression in four tumor tissues samples with corresponding normal lung tissues samples. And the lower panel indicates the quantification of SIRT2 protein level in NSCLC tissues and corresponding normal lung tissues (n = 40, ****P < 0.0001). (D,E) The expression of TFEB in LUAD patients (t = 483, n = 347) and the OS curves of TFEB^high (n = 239) and TFEB^low (n = 239) NSCLC patients. (F) The expression of TFEB was detected in human NSCLC tissues, the upper panel shows the expression of TFEB in four tumor tissues samples with corresponding normal lung tissues samples. And the lower panel indicates the quantification of SIRT2 protein level in NSCLC tissues and corresponding normal lung tissues (n = 40, ***P < 0.001). (G,H) IHC staining detected the expression of SIRT2 and TFEB in human NSCLC tissues (n = 40, **P < 0.01).