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. 2020 Dec 3;8:596777. doi: 10.3389/fcell.2020.596777

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Copyright © 2020 Qi, Qu, Tu, Lu, Li, Wang and Qu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lasso penalized Cox regression analysis of SE-associated 410 genes. (A,B) The coefficient values at varying levels of penalty. (C) The identification of best Lambda value. The left solid vertical line is the logarithm of lambda.min (35-gene group), the right solid vertical line is the logarithm of lambda.1se (13-gene group). (D) Two models based on lambda.lse and lambda.min are used to distinguish the survival and death events by the Wilcoxon test. (E) ROC curves are used to compare the predictive performance for prob-min and prob-1se to predict patient survival.