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. 2020 Dec 3;8:621428. doi: 10.3389/fcell.2020.621428

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Copyright © 2020 Xu, Yuan, Tang, Xu, Xu, Cheng and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The roles of p53 and PTEN signaling pathways in the regulation of autophagy. (1) p53 pathway: nuclear p53 can induce autophagy through Sestrin1/Sestrin2-AMPK-TSC1/TSC2 complex-mTOR. DRAM is a downstream target of p53 facilitating autophagy. Furthermore, p53 can induce DAPK1 to phosphorylate Beclin-1 or bind to MAP1B to inhibit autophagy. However, cytoplasmic p53 blocks AMPK, TIGAR, and Beclin-1 to inhibit autophagy. (2) PTEN pathway: PTEN has crosstalk with other signal pathways. PTEN can induce autophagy through the PTEN/AKT/FOXO3a/Atg7 pathway, independent of mTOR and Beclin-1. Additionally, PTEN blocks the release of cytochrome c to induce autophagy.