TABLE 1.

Key regulatory proteins in autophagy-mediated chemoresistance of gastric cancer.

Protein	Expression in GC	Effects on autophagy	Chemotherapy	Effects on chemosensitivity	Downstream pathways	References
WASF3	NA	Inducing	OXA	Decreasing	ATG12	Nie et al., 2020
PLK1	Up	Inducing	DDP	Decreasing	CDC25C, cyclin B1, LC3-I, LC3-II	Chen et al., 2019
AQP3	Up	Inducing	DDP	Decreasing	Atg5, Beclin-1, P62	Dong et al., 2016
DJ-1	Up	Inducing	EPI	Decreasing	LC3-I, LC3-II	Pan et al., 2018
TSPAN9	Up	Inducing	5-FU	Decreasing	PI3K/AKT/mTOR	Qi et al., 2020
CD133	Up	Inducing	DDP	Decreasing	PI3K/AKT/mTOR	Lu et al., 2019
TRIM14	Up	Inducing	5-FU, OXA	Decreasing	AMPK/mTOR	Xiao et al., 2020
MTDH	Up	Inducing	5-FU	Decreasing	AMPK/ATG5	Pei et al., 2018
ERAS	Up	Inhibiting	DDP	Decreasing	AKT/mTOR	Tian et al., 2019
CCL2	Up	Inhibiting	DDP	Decreasing	PI3K/AKT/mTOR, SQSTM1	Xu et al., 2018b
RAB5A	Up	Inhibiting	DDP	Decreasing	mTOR	Xu et al., 2018a
MGMT	NA	Inhibiting	DDP	Increasing	ATG4B	Lei et al., 2020
CISD2	Down	Inhibiting	5-FU	Increasing	AKT/mTOR	Sun et al., 2017

5-FU, 5-fluorouracil; DDP, cisplatin; EPI, epirubicin; GC, gastric cancer; OXA, oxaliplatin; NA, not applicable.