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. 2020 Dec 3;11:548268. doi: 10.3389/fgene.2020.548268

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Copyright © 2020 Cui, Zhang, Zhang, Guo, Wu, Yao and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MicroRNAs represses the expression of M-SAA3.2 via binding the 3’UTR target sequence. Luciferase activity in HEK293 cells co-transfected with miRNA mimic, miRNA inhibitor, miRNA control and empty vector for the M-SAA3.2 3’UTR. Luciferase activity was assayed 24 h after transfection. All luciferase values were normalized to Renilla luciferase. The meanings of different colors are consistent with Figure 5. (A,C,E) Represents the luciferase activity of M-SAA3.2 after over- or down-expressed miR-146b, miR-339a and miR-339b compared with controls, respectively. (B,D,F) Represents the luciferase activity of M-SAA3.2 after transfecting mutant vector of miR-146b, miR-339a and miR-339b compared with control, respectively. **Very significant difference between the control and the treatment.