TABLE 3.
KEGG pathways assigned to the predicted target genes of the 497 known and 49 novel miRNAs identified in this study.
| Pathways | Input number | p-Value | Differentially expressed target genes identified in our previous RNA-Seq studya,18 |
| Lysosome | 101 | 0.00015 | |
| MAPK signaling pathway | 182 | 0.00026 | NR4A1, DDIT3 |
| Endocytosis | 182 | 0.00030 | |
| Leukocyte transendothelial migration | 89 | 0.00119 | |
| Adherens junction | 52 | 0.00166 | |
| Glycosaminoglycan biosynthesis | 11 | 0.00257 | |
| Chagas disease (American trypanosomiasis) | 82 | 0.00260 | |
| mTOR signaling pathway | 108 | 0.00270 | VEGFA |
| Synaptic vesicle cycle | 47 | 0.00289 | |
| Adipocytokine signaling pathway | 49 | 0.00299 | |
| Bacterial invasion of epithelial cells | 59 | 0.00299 | |
| Tight junction | 102 | 0.00304 | |
| Collecting duct acid secretion | 24 | 0.00324 | |
| Pertussis | 61 | 0.00327 | |
| Glycosphingolipid biosynthesis | 11 | 0.00345 | |
| SNARE interactions in vesicular transport | 30 | 0.00355 | |
| Glutathione metabolism | 44 | 0.00557 | |
| Homologous recombination | 23 | 0.00774 | |
| Fc gamma R-mediated phagocytosis | 68 | 0.01124 | |
| Linoleic acid metabolism | 28 | 0.02387 | |
| Pyrimidine metabolism | 87 | 0.02475 | |
| Alpha-linolenic acid metabolism | 20 | 0.02550 | |
| Glycerophospholipid metabolism | 75 | 0.03191 | |
| HIF-1 signaling pathway | 78 | 0.03455 | VEGFA, CDKN1A |
| PI3K-Akt signaling pathway | 241 | 0.03942 | VEGFA, CDKN1A |
| Apoptosis | 22 | 0.04444 | |
| Arachidonic acid metabolism | 55 | 0.04654 | |
| DNA replication | 29 | 0.04704 |
KOBAS software was used to test the statistical enrichment of the candidate target genes in the KEGG pathways. aNR4A1, nuclear receptor subfamily 4, group A, member 1; DDIT3, DNA-damage-inducible transcript 3; VEGFA, vascular endothelial growth factor A; CDKN1A,cyclin-dependent kinase inhibitor 1A.