TABLE 4.
KEGG pathways assigned to the predicted target genes of the 71 differentially expressed miRNAs identified in this study.
| Pathways | Input number | p-Value | Differentially expressed genes identified in our previous RNA-Seq studya,20 |
| Glutathione metabolism | 27 | 0.015447 | |
| p53 signaling pathway | 33 | 0.01608 | CDKN1A |
| Synaptic vesicle cycle | 30 | 0.020395 | CDKN1A |
| Cell cycle | 51 | 0.027481 | |
| NF-kappa B signaling pathway | 39 | 0.030627 | |
| Fc gamma R-mediated phagocytosis | 37 | 0.035842 | |
| Collecting duct acid secretion | 15 | 0.047867 | CDKN1A |
| mTOR signaling pathway | 51 | 0.027261 | VEGFA |
| Fatty acid degradation | 15 | 0.03017 | |
| Fatty acid metabolism | 18 | 0.030625 | DDIT3 |
| Protein processing in endoplasmic reticulum | 49 | 0.040795 |
KOBAS software was used to test the statistical enrichment of the candidate target genes in the KEGG pathways. aNR4A1, nuclear receptor subfamily 4, group A, member 1; DDIT3, DNA-damage-inducible transcript 3; VEGFA, vascular endothelial growth factor A; CDKN1A,cyclin-dependent kinase inhibitor 1A.