Fig. 2.

Examples of native P53 DBD structure and the variant-affected structure after 40 ns simulation. The well-determined Pathogenic variant R175H unbounded L1, L2 and L3 loops, in contrast to the intact core in the well-determined Benign variant N235S. Red colour shows the variants. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)