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. 2020 Dec 13;6(7):1878–1909. doi: 10.1016/j.bioactmat.2020.12.001

Fig. 9.

Fig. 9

Preparation of multi-prodrug nanocarriers with the activated release behavior of PTX and gemcitabine in targeted cancer cells. Multi-prodrug nanocarriers were constructed via electrostatic interactions between PLL-PTX and hyaluronic acid-gemcitabine and taken up by CD44-mediated endocytosis, followed by hydrolyzing ester linkage of the prodrug conjugates in acidified endosomes, thereby leading to synergistic apoptosis. Reproduced with permission from Ref. [233], copyright 2015, Elsevier.