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. 2020 Dec 3;11:587189. doi: 10.3389/fendo.2020.587189

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Copyright © 2020 Iizuka, Takao and Yabe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential regulation of monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) synthesis by ChREBP and SREBP-1c. Both ChREBP and SREBP-1c regulate MUFA synthesis by regulating the expression of genes involved in fatty acid synthesis (e.g., Acc1 and Fasn), elongation (e.g., Elovl6), and desaturation (e.g., Scd1); whereas SREBP-1c, but not ChREBP, regulates PUFA synthesis by regulating the expression of genes involved in elongation (e.g., Elovl2) and desaturation [e.g., fatty acid desaturase 1 (Fasd1) and fatty acid desaturase 2 (Fasd2)]. PUFAs suppress the transcriptional activities of ChREBP and SREBP-1c. ACC1, acetyl CoA carboxylase; FASN, fatty acid synthase; ELOVL6, fatty acid elongase 6; SCD1, stearyl CoA desaturase; ELOVL5, fatty acid elongase 5; FASD1, fatty acid desaturase 1; FASD2, fatty acid desaturase 2.